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In the event of overdose, anaesthetic effects may occur with signs of excessive drowsiness, (including loss of consciousness), lowering of blood pressure, respiratory depression, pallor and muscle relaxation. After PENTHROX discontinuation such overdose effects usually resolve quickly often with no other intervention required but cardiorespiratory supportive measures should be implemented if necessary.
High doses of methoxyflurane cause dose related nephrotoxicity. High output renal failure has occurred several hours or days after the administration of repeated high analgesic or anaesthetic doses of methoxyflurane.
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