Penthrox Dosage/Direction for Use

PENTHROX should be self-administered under supervision of a person trained in its administration, using the hand held PENTHROX Inhaler.
One bottle of 3 mL PENTHROX to be vaporised in a PENTHROX inhaler. On finishing the 3 mL dose, another 3 mL may be used. Dose of PENTHROX should not exceed 6 mL in a single administration. Administration on consecutive days is not recommended and the total dose to a patient in a week should not exceed 15 ml (see Precautions).
Onset of pain relief is rapid and occurs after 6-10 inhalations. Patients should be instructed to inhale intermittently to achieve adequate analgesia. Patients are able to assess their own level of pain and titrate the amount of PENTHROX inhaled for adequate pain control. With continuous inhalation, 3 ml PENTHROX provides analgesic relief for up to 25-30 minutes. Intermittent inhalation may provide longer analgesic relief. Patients should be advised to take the lowest possible dose to achieve pain relief.
PENTHROX should not be used in children under 18 years.
Method of Administration: Instructions on the preparation of the PENTHROX Inhaler and correct administration are provided as follows: 1. Ensure the optional Activated Carbon (AC) Chamber is inserted into the dilutor hole on the top of the PENTHROX Inhaler.
2. Remove the cap of the bottle by hand. Alternatively, use the base of the PENTHROX Inhaler to loosen the cap with a ½ turn. Separate the Inhaler from the bottle and remove the cap by hand.
3. Tilt the PENTHROX Inhaler to a 45° angle and pour the total contents of one PENTHROX bottle into the base of the Inhaler whilst rotating.
4. Place wrist loop over patient's wrist. Instruct patient to inhale through the mouthpiece of the PENTHROX Inhaler to obtain analgesia. First few breaths should be gentle and then breathe normally through Inhaler.
5. Instruct patient to exhale into the PENTHROX Inhaler so the exhaled vapour passes through the AC Chamber which adsorbs any exhaled methoxyflurane.
6. If stronger analgesia is required, instruct patient to cover dilutor hole on the Inhaler or AC chamber with finger during use.
7. Instruct patient to inhale intermittently to achieve adequate analgesia. Continuous inhalation will reduce duration of use. Minimum dose to achieve analgesia should be administered.
8. Replace cap onto PENTHROX bottle. Place used PENTHROX Inhaler and used bottle in sealed plastic bag and dispose of responsibly.