Penthrox Adverse Reactions

Summary of safety profile: The most frequently observed non-serious reactions to PENTHROX are CNS type reactions such as dizziness, and somnolence, and are generally easily reversible.
Serious dose-related nephrotoxicity has only been associated with methoxyflurane when used in large doses over prolonged periods during general anaesthesia. Methoxyflurane is therefore no longer used for anaesthesia. See Renal disease under Precautions. The recommended maximum dose for PENTHROX should therefore not be exceeded.
Liver injury may occur rarely (less than 1 case per 1,000 patients) and hepatic enzymes increased may occur uncommonly (less than 1 case per 100 patients) with analgesic use of methoxyflurane. See Liver disease under Precautions.
Tabulated list of adverse reactions: The adverse drug reactions related to PENTHROX observed in clinical studies and treatment-emergent events from postmarketing sources are listed in the table as follows, classified according to frequency (very common ≥1/10; common ≥1/100 to <1/10; uncommon ≥1/1,000 to <1/100; rare ≥1/10,000 to <1/1,000; very rare <1/10,000; and not known (cannot be estimated from the available data)). See table.

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