Sign Out
Pharmacology: Pharmacodynamics: Omeprazole is an antisecretory compound classified as substituted benzimidazole, which exhibits suppression of gastric acid secretion by specific inhibition of H+/K+/ATPase enzyme system at the secretary surface of gastric parietal cell; and has no effect on anticholinergic or histamine antagonist properties. This effect of Omeprazole is dose-related and inhibits basal and stimulated acid secretion regardless on the stimulus.
Pharmacokinetics: Omeprazole has a saturable first-pass effect that metabolized in liver by CYP450, isoenzyme CYP2C19 and CYP3A4 into inactive metabolites and excreted in urine and rarely in bile. It has high plasma protein binding which is approximately about 95% and a half-life of 0.5-3.5 hours. The duration of action is 72 hours and the onset of action is within 1 hour. While, the acid inhibitory effect lasts more than 24 hours; therefore, the administration of Omeprazole once daily is adequate. This is reversible control as when the drug is discontinued, secretary activity returns over 1-5 days.
