O-Sid Drug Interactions

As Omeprazole is metabolized by CYP450, isoenzyme CYP2C19 and CYP3A4, the use of the drug with diazepam, phenytoin, and warfarin should be concerned as it will prolong the elimination of these agents. Warfarin may have an effect on prothrombin time; the administration of the drug should be frequently monitored.
The absorption rate of dasatinib, ketoconazole, itraconazole will be decreased when administered with Omeprazole as the absorption of these agents depends on the acid and basic condition in the stomach.
The concentration of voriconazole, clarithromycin and digoxin in plasma will be increased with the concomitant use of Omeprazole and other proton pump inhibitors.
The activity of atazanavir will be decreased when administered with Omeprazole and other proton pump inhibitors.
Increasing in toxicities and adverse effects of cilostazol are reported when used with Omeprazole, the dose of cilostazol should be monitored and adjusted.
Gastric irritation effect from the use of salicylate drugs may be potentiated due to the increasing of solubility of the agent when administered with Omeprazole.
The level of Sulfonylureas in plasma will be raised, resulting in hypoglycemic phenomena. The dose should be monitored when administered with Omeprazole and other proton pump inhibitors.
Coadministration of proton pump inhibitors with sucralfate will delay the absorption and bioavailability of proton pump inhibitors.
Administration of Omeprazole and other proton pump inhibitors with benzodiazepines; for such diazepam, triazolam, may reduce the clearance, prolongs the half-life and increases the serum level of benzodiazepines. The dosage should be monitored and adjusted.