Sign Out
Propofol has been used in association with spinal and epidural anesthesia and with commonly used pre-medicants, neuromuscular blocking drugs, inhalational agents and analgesic agents; no pharmacological incompatibility has been encountered. Lower doses of Nupovel may be required where general anesthesia is used as an adjunct to regional anesthetic techniques.
Profound hypotension has been reported following anesthetic induction with propofol in patients treated with rifampicin.
The concurrent administration of other CNS depressants such as pre-medication drugs, inhalation agents, analgesic agents may add to the sedative, anesthetic and cardiorespiratory depressant effects of propofol.
A need for lower propofol doses has been observed in patients taking valproate. When used concomitantly, a dose reduction of propofol may be considered.
