Sign Out
Supplementary analgesic medical products are generally required in addition to Nupovel.
Nupovel is given intravenously. The dosage is adjusted individually according to the patient's response.
Induction and maintenance of general anaesthesia: Induction of anaesthesia in adults: For induction of anaesthesia Nupovel should be titrated (20-40 mg of propofol every 10 seconds) against the patient's response until the clinical signs show the onset of anaesthesia. Most adult patients younger than 55 years are likely to require 1.5 to 2.5 mg of propofol/kg body weight (BW).
In older patients and in patients of ASA grades III and IV, especially those with impaired cardiac function, the dosage requirements will be less and the total dose of Nupovel may be reduced to 1 mg of propofol/kg BW or less. In these patients lower rates of administration should be applied (approximately 2 mL, corresponding to 20 mg, every 10 seconds).
Maintenance of anaesthesia in adults: Anaesthesia can be maintained by administering Nupovel either by continuous infusion or by repeat bolus injections. If a technique involving repeat bolus injections is used, increments of 25-50 mg of propofol (2.5-5.0 mL) may be given according to clinical requirements. For maintenance of anaesthesia by continuous infusion the dosage requirements usually are in the range of 4-12 mg/kg BW/h.
In the elderly, in patients of poor general condition, in patients of ASA grades III and IV and in hypovolaemic patients the dosage may be reduced further depending on the severity of the patient's condition and on the performed anaesthetic technique.
Induction of anaesthesia in children over 1 month of age: For induction of anaesthesia Nupovel should be titrated slowly against the patient's response until the clinical signs show the onset of anaesthesia. The dosage should be adjusted according to age and/or body weight. Most patients over 8 years require approximately 2.5 mg of propofol/kg BW for induction of anaesthesia. In younger children, especially between the age of 1 month and 3 years, dose requirements may be higher (2.5-4 mg of propofol/kg BW).
Maintenance anaesthesia in children over 1 month of age: Anaesthesia can be maintained by administering Nupovel by infusion or repeated bolus injection to maintain the depth of anaesthesia required. The required rate of administration varies considerably between patients but rates in the region of 9-15 mg/kg/h usually achieve satisfactory anaesthesia. In younger children, especially between the age of 1 month and 3 years, dose requirements may be higher.
For ASA III and IV patients lower doses are recommended.
Sedation for diagnostic and surgical procedures in adults: To provide sedative during surgical and diagnostic procedures, doses and administration rates should be adjusted according to the clinical response. Most patients will require 0.5-1 mg of propofol/kg BW over 1 to 5 minutes for onset of sedation. Maintenance of sedation may be accomplished by titrating Nupovel (10 mg/mL) infusion to the desired level of sedation. Most patients will require 1.5-4.5 mg of propofol/kg BW/h. The infusion may be supplemented by bolus administration of 10-20 mg of propofol (1-2 mL) if a rapid increase of the depth of sedation is required.
In patients older than 55 years and in patients of ASA grades III and IV lower doses of propofol 10 mg/mL may be required and the rate of administration may need to be reduced.
Sedation for diagnostic and surgical procedures in children over 1 month of age: Doses and administration rates should be adjusted according to the required depth of sedation and the clinical response. Most paediatric patients require 1-2 mg/kg body weight of propofol for onset of sedation. Maintenance of sedation may be accomplished by titration Nupovel (10 mg/mL) as infusion to the desired level of sedation. Most patients require 1.5-9 mg/kg/h of propofol. The infusion may be supplemented by bolus administration of up to 1 mg/kg b.w. if a rapid increase of depth of sedative is required.
For ASA III and IV patients lower doses are recommended.
Sedation of ventilated patients in the intensive care unit: For sedation during intensive care it is advised that Nupovel be given by continuous infusion. The infusion rate should be determined by the required depth of sedative. In most patients sufficient sedation can be obtained with a dosage of 0.3-4.0 mg of propofol/kg BW/h.
Administration of propofol by Target Controlled Infusion (TCI) system is not advised for sedation in the intensive care unit.
Propofol is not indicated for sedation in intensive care of patients of 16 years of age or younger.
Mode of administration: Nupovel can be used for infusion undiluted or diluted with 5% dextrose (intravenous infusion) only. Dilutions, which must not exceed 1 in 5 (propofol 2 mg/mL), should be prepared aseptically immediately before administration and must be used within 6 hours of preparation.
It is recommended that, when using diluted Nupovel, the volume of 5% dextrose removed from the infusion bag during the dilution process is totally replaced in volume by Nupovel (see "Dilution and Co-administration" Table as follows).
When propofol is used undiluted to maintain anaesthesia, it is recommended that equipment such as syringe pumps or volumetric infusion pumps should always be used to control the infusion rates.
Containers should be shaken before use.
Nupovel may be administered via a Y-piece close to the injection site into infusions of the following: Dextrose 5% intravenous infusion; Sodium chloride 0.9% intravenous infusion; Dextrose 4% and sodium chloride 0.18% intravenous infusion.
In order to reduce pain on initial injection, it may be mixed with preservative-free lidocaine injection 0.5% or 1% as a ratio 1:20 with Nupovel (see Table as follows).
Click on icon to see table/diagram/image