Very common (may affect more than 1 in 10 people): A feeling of pain at the site of the injection (while the injection is being given, before the patient falls asleep).
Common (may affect up to 1 in 10 people): Low blood pressure.
Changes in the breathing pattern.
Slow heartbeat.
Rare (may affect up to 1 in 1,000 people): Twitching and shaking of the body, or a fit (may also happen when the patient wakes up).
Unusual colour of urine (may also happen when the patient wakes up).
Very rare (may affect up to 1 in 10,000 people): Allergic reactions.
Stopping of the heartbeat.
Build up of fluid in the lungs which can make the patient very breathless (may also happen when the patient wakes up).
Not known: frequency cannot be estimated from the available data: Shallow breathing.
Priapism.
Side effects that can happen after anesthesia: The following side effects can happen after anesthesia (when the patient is waking up or after the patient has woken up).
Common (may affect up to 1 in 10 people): Feeling sick (nausea).
Being sick (vomiting).
Headache.
Uncommon (may affect up to 1 in 100 people): Swelling and redness along a vein or blood clots.
Very rare (may affect up to 1 in 10,000 people): Feeling sexually aroused.
High temperature (fever).
Redness or soreness where the injection was given.
Being unconscious after the operation. (When this has happened, the patients have recovered without problems).
Tissue damage.
Not known: frequency cannot be estimated from the available data: A feeling of pain at the site of the injection.
Swelling at the site of injection.
Prolonged, often painful erection (priapism).
Other possible side effects: The following side effects have been seen when Propofol is used in intensive care at higher doses than recommended.
Very rare (may affect up to 1 in 10,000 people): Heart failure.
Inflamed pancreas (pancreatitis) which causes severe stomach pain.
Too much acid in the blood. This may make the patient breathe more quickly.
Increased amount of potassium in the blood.
High blood level of a type of fat called lipids.
Abnormal heart beat.
Enlargement of the liver.
Kidney failure.
The following side effects have been seen in children in intensive care when Propofol has been stopped suddenly.
Common (may affect up to 1 in 10 people): 'Withdrawal symptoms'. These include unusual behavior, sweating, shaking and feeling anxious.
Flushing of the skin.
Not known: frequency cannot be estimated from the available data: Euphoric mood.
Involuntary movements.
Drug abuse and dependence on Propofol, mostly by healthcare professionals.
Abnormal ECG.
Breakdown of muscle cells (rhabdomyolysis).
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