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Pharmacology: Pharmacodynamics: Nicardipine is a dihydropyridine calcium channel blockers which share the ability to inhibit movement of calcium ions across the cell membrane of the myocardium and vascular smooth muscle. The effects on the cardiovascular system include depression of mechanical contraction of myocardial and smooth muscle and depression of both impulse formation and conduction velocity.
Pharmacokinetics: Nicardipine has a volume of distribution about 8.3 L/kg and protein binding >95%. The elimination half-life varies from about 2-4 hours. It is metabolised in the liver. Excretion in urine is about 49% (as <1% unchanged form) and in feces is about 43%.
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