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Coadministration with beta-blockers agents may cause additive or synergistic effects. Nicardipine may inhibit the metabolism of certain beta-blockers. Monitor cardiac function and adjust dosage as needed.
Cyclosporine level and toxicity may be increased when given concurrently with nicardipine.
Serum concentrations of nicardipine may be increased when given concurrent with cimetidine. Adjust dose as needed.
Coadministration with rifampin may decrease the therapeutic effects of nicardipine. Monitor cardiovascular status closely. Adjust dose as needed.
Grapefruit juice may increase the serum concentrations of nicardipine.
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