IV infusion Administer as slow continuous infusion at 0.1 mg/mL conc. Infusion site should be changed every 12 hr if administered via peripheral vein. BP reduction Initially 50 mL/hr (5 mg/hr). If desired BP reduction is not achieved at this dose, infusion rate may be increased by 25 mL/hr (2.5 mg/hr) 15 min for gradual BP reduction, or every 5 min for more rapid BP reduction, up to max of 150 mL/hr. Following achievement of BP goal in rapid BP reduction, the infusion rate should be decreased to 30 mL/hr (3 mg/hr). Hypotension or tachycardia Infusion may be restarted at low doses eg, 30-50 mL/hr (3-5 mg/hr) & adjusted to maintain desired BP when BP has stabilized.
CHF; coronary ischemia; increased angina. Monitor BP during & after infusion. Avoid abrupt or excessive reduction in BP during therapy. Hepatic or renal impairment. Not advisable during pregnancy & for nursing mother. Not recommended in ped patients.
C08CA04 - nicardipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
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