Metrolex Special Precautions

Metronidazole should be used with caution in patients with central nervous system disease. Continuous therapy for periods longer than those recommended are advised to consider the risk of peripheral neuropathy.
Metronidazole was carcinogenic in mice and rats. Unnecessary use of Metronidazole should be avoided, and the drug should be used only as stated in indication.
Use the drug with caution in the elderly and in reduced dosage in patients with hepatic impairment. Plasma Metronidazole concentration should be monitored regularly.
METROLEX should be used with caution in patients with a history of blood dyscrasias, and leukocyte counts should be performed before and after treatment with the drug.
Concurrent use of METROLEX and alcoholic beverage is contraindicated. Disulfiram-like reactions have occurred in some patients who ingested alcohol while receiving METROLEX.
Injection: This Metronidazole injection product should be used with caution in patients who need restrict sodium content, in patients receiving corticosteroids and in patients predisposed to edema because the Metronidazole injection contains 0.9% sodium chloride solution.
Candidiasis infection maybe more prominent during Metronidazole treatment, antifungal treatment required.