Metrolex Indications/Uses

Metronidazole is used in the prevention/prophylaxis and treatment of infectious diseases caused by susceptible anaerobic bacteria as follows: Urogenital (tablet)/sexually transmitted (injection) infection in either male or female caused by Trichomonas sp.
Bacterial vaginosis caused by Trichomonas sp. and anaerobic bacterial infection in vagina including non-specific vaginitis, anaerobic vaginosis, or Gardnerella vaginitis.
Amoebiasis, both intestinal and extraintestinal disease, caused by Entamoeba histolytica.
Diarrhea caused by Giardia sp. (Giardiasis).
Anaerobic bacterial septicemia, such as septicemia and bacteremia, caused by Bacteroides sp. and Clostridium sp.
Intra-abdominal anaerobic bacterial infections including peritonitis, intra-abdominal abscess, and liver abscess caused by Bacteroides sp., Clostridium sp., Eubacterium sp., Peptococcus niger and Peptostreptococcus sp.
Central nervous system anaerobic bacterial infections including brain abscess and meningitis caused by Bacteroides sp.
Lower respiratory tract anaerobic bacterial infections including pneumonia, empyema, and lung abscess caused by Bacteroides sp.
Skin and skin structure anaerobic bacterial infections including bone and joint infections caused by Bacteroides sp., Clostridium sp., Peptococcus niger, Peptostreptococcus sp. and Fusobacterium sp.
Acute necrotizing ulcerative gingivitis.
Prevention of post-operative infections due to anaerobic bacteria particularly caused by Bacteroides sp.
Tablet: Acute dental infections (e.g. acute pericoronitis and acute apical infections).
Injection: This includes severe infection as well as intraoperative and postoperative surgical prophylaxis to reduce incidence of infection. Metronidazole is effective in Bacteroides fragilis infection which failed to respond to clindamycin, chloramphenicol, penicillin.