Methima Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Methimazole

Indications/Uses

Hyperthyroidism.

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Dosage/Direction for Use

Adult Mild hyperthyroidism Initially 15 mg once daily in 3 divided doses. Moderate to severe hyperthyroidism 30-40 mg once daily in 3 divided doses. Severe hyperthyroidism 60 mg once daily in 3 divided doses. Total daily dose: Usually given in 3 equally divided doses at approx 8-hr interval. Maintenance dose: 5-15 mg once daily. May be given as single daily dose in many cases. Childn Initially 0.4 mg/kg once daily in 3 equally divided doses at approx 8-hr interval. Maintenance dose: 0.2 mg/kg once daily in 3 equally divided doses at approx 8-hr interval.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Risk to cross-sensitivity when switching from 1 thioamide agent to other. Not recommended to use alternative antithyroid drug ie, propylthiouracil.

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Special Precautions

Discontinue treatment if pruritic rash, jaundice, alcoholic stools, dark urine, arthralgias, abdominal pain or fatigue occurs; in the presence of hepatitis (transminase >3x ULN). Monitor for signs or symptoms of illness eg, sore throat, skin eruptions, fever, chills, headache or general malaise. Agranulocytosis; aplastic anemia, thrombocytopenia & leukopenia; hypoprothrombinemia & bleeding; hypothyroidism. Patients receiving other drugs causing myelosuppression (particularly agranulocytosis) & in patients >40 yr. Avoid doses ≥40 mg daily. Perform baseline CBC including white count differential; LFT including alkaline phosphatase, aminotransferase & bilirubin prior to therapy. Monitor prothrombin time during therapy, especially before surgical procedures; thyroid function every 1-3 mth for 6-12 mth after discontinuation & if symptoms of hyperthyroidism occur. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

ANCA-positive vasculitis, edema; drowsiness, fever, headache, neuritis, vertigo; alopecia, exfoliative dermatitis, pruritus, skin pigmentation, skin rash, urticarial; goiter, hypoglycemic coma; constipation, epigastric distress, loss of taste perception, nausea, salivary gland swelling, vomiting, wt gain; agranulocytosis, aplastic anemia, granulocytopenia, hypoprothrombinemia, leukopenia, thrombocytopenia; hepatic necrosis, hepatitis, jaundice; arthralgia, myalgia, paresthesia; nephritis, insulin autoimmune syndrome, lympadenopathy, SLE-like syndrome.

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Drug Interactions

Increased levels/effects of aripiprazole, cardiac glycosides, clozapine, lomitapide, pimozide, theophylline derivatives. Decreased levels/effects of Na iodide, vit K antagonists.

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Storage

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Description

View Methima description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antithyroid Agents

ATC Classification

H03BB02 - thiamazole ; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.

Thai FDA Category

Presentation/Packing

Form

Methima tab 5 mg

Packing/Price

50 × 10's

Methima

thiamazole

Manufacturer:

Charoon Bhesaj

Distributor:

Charoon Bhesaj

Marketer:

Charoon Bhesaj