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Overdosage: In general, overdosage of methimazole may be expected to produce effects that are extensions of common adverse reactions. Symptoms may include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus and edema. Aplastic anemia (pancytopenia) or agranulocytosis may be manifested in hours to days. Agranulocytosis is the most serious effect associated with methimazole overdosage. Less frequent adverse effects include exfoliative dermatitis, hepatitis, nephrotic syndrome, neuropathies and CNS stimulation or depression. No data are available on the median lethal dose of methimazole or the concentration of drug in biologic fluids associated with toxicity and/or death.
Treatments: Treatment of methimazole overdosage generally involves appropriate supportive care as dictated by the patient's medical status.
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