Ketocetz Use In Pregnancy & Lactation

Pregnancy: Category C: Ketorolac crosses the placenta. The use of ketorolac is contraindicated in labor and delivery. Inhibition of prostaglandin synthesis by ketorolac affects fetal circulation and uterine contraction, resulting in uterine hemorrhage. Safety for use of NSAIDs during pregnancy has not been fully established. NSAIDs exposure during the first trimester is not strongly associated with congenital malformations. Nonteratogenic effects of NSAIDs have been observed during the third trimester, including myocardial degenerative changes, premature closure of ductus arteriosus, fetal tricuspid regurgitation, renal dysfunction, oligohydramnios, bleeding disorder, and gastrointestinal bleeding or perforation.
Lactation: Most NSAIDs, including ketorolac, are excreted into breast milk. Safety of ketorolac in pediatric patients has not been established. Because of the potential risks to breast-feeding infants, ketorolac tromethamine should not be used in lactating women.