Ketocetz Drug Interactions

Probenecid: Probenecid may increase the concentrations and toxicity of NSAIDs, including ketorolac tromethamine. Therefore, concomitant use of probenecid and ketorolac tromethamine is contraindicated.
Non-steroidal anti-inflammatory agents (NSAIDs): Concomitant use of ketorolac tromethamine and other NSAIDs, including aspirin, leads to increased risk of serious NSAID-related adverse reactions. Patients receiving any NSAIDs or aspirin should not use ketorolac tromethamine.
Pentoxifylline: Concomitant use of pentoxifylline and ketorolac tromethamine may increase the tendency for bleeding. Concomitant use of pentoxifylline and ketorolac tromethamine is contraindicated.
Drugs with reported adverse interactions with NSAIDs: The adverse interactions with NSAIDs of the following drugs have been observed. These drugs should not be used concomitantly with NSAIDs, including ketorolac tromethamine: Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers; Antidepressants (tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors, and selective serotonin reuptake inhibitors); Antiplatelets and anticoagulants; Beta-adrenergic blockers; Cyclosporine; Digoxin; Diuretics (potassium sparing diuretics, thiazide diuretics, and loop diuretics); Fluoroquinolones; Lithium; Methotrexate and derivatives (pemetrexate and pralatrexate); Oral corticosteroids; Tenofovir disoproxil fumarate.
Admixture compatibility: Ketorolac tromethamine injection should not be mixed in a small volume container or syringe with morphine, meperidine, promethazine, or hydroxyzine since precipitation of ketorolac tromethamine may occur.