Kestine Special Precautions

Administer with caution in patients with known cardiac risk such as patients with prolonged QT interval, hypokalaemia, concomitant treatment with compounds increasing QT interval or inhibiting enzyme CYP3A4, such as azole antifungal agents like ketoconazole and itraconazole and macrolide antibiotics like erythromycin (see Interactions).
Pharmacokinetic interactions could occur when administering ebastine with rifampicin (see Interactions).
Ebastine should be used with caution in patients with severe hepatic impairment (see Dosage & Administration).
Given that ebastine reaches its therapeutic effect between 1 and 3 hours after administration, it should not be used in emergency allergy situations.
Warnings about excipients: This medication contains lactose. Patients with hereditary galactose intolerance, Lapp lactase deficiency (deficiency observed in some populations in Lapland) or poor absorption of glucose or galactose should not take this medication.
Effects on ability to drive and use machines: The psychomotor function has been widely studied in humans with no observed effects. At the recommended therapeutic doses ebastine does not affect the ability to drive or to use machinery.
However, in sensitive individuals who react unusually to ebastine, knowledge of their individual reactions is recommended before the patient drives or carries out complex activities: drowsiness or dizziness could appear (see Adverse Reactions).