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Use in pregnancy: The daily oral administration of cephalexin to rats in doses of 250 or 500 mg/kg prior to and during pregnancy, or to rats and mice during the period of organogenesis only, had no adverse effects on fertility, fetal viability, fetal weight or litter size. Note that the safety of cephalexin during pregnancy in humans has not been established.
Cephalexin showed no enhanced toxicity in weaning and newborn rats as compared with adult animals. Nevertheless, because the studies in humans cannot rule out the possibility of harm, cephalexin should be used during pregnancy only if clearly needed.
Use in lactation: The excretion of cephalexin in the milk increased up to 4 hrs after a 500-mg dose: The drug reached a maximum level of 4 mg/L, then decreased gradually, and had disappeared 8 hrs after administration. Caution should be exercised when cephalexin is administered to a nursing woman.
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