K-CIL Special Precautions

Hematologic: During long-term therapy, renal, hepatic and hematopoietic functions should be checked periodically.
Hepatic: During long-term therapy, renal, hepatic and hematopoietic functions should be checked periodically.
Immune: Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients receiving penicillin or cephalosporin therapy. These reactions are more apt to occur in individuals with a history or sensitivity to multiple allergens. Careful inquiry should be made concerning previous hypersensitivity to reactions to penicillins, cephalosporins or other allergens. If allergic or anaphylactic reactions occurs, discontinue treatment and administer the usual agents, e.g. antihistamines, pressor amines, corticosteroids. See Contraindications.
Neurologic: The passage of any penicillin from blood into brain is facilitated by inflamed meninges and during cardiopulmonary bypass. In the presence of such factors, particularly in renal failure when high serum concentration can be attained, CNS adverse effects including myoclonia, convulsive seizures and depressed consciousness can be expected. Although this complication has not been reported with cloxacillin, it should be anticipated.
Sensitivity/Resistance: Candidiasis and other superinfections may occur, especially in debilitated and malnourished patients, or those with low resistance to infection due to corticosteroids, immunosuppressors or irradiation. If superinfection occurs, institute appropriate measures.
Renal: During long-term therapy, renal, hepatic and hematopoietic functions should be checked periodically.
Susceptibility/Resistance: Development of Drug Resistant Bacteria: Prescribing Cloxacillin for Injection in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and risks the development of resistant organisms.
Effects on ability to drive and use machines: Adverse effects on the ability to drive or operate machinery have not been observed.
Use in Children: Experience in premature and newborn infants is limited. Cautious administration of the drug to such patients and frequent evaluation of organ system function is recommended.