K-CIL Dosage/Direction for Use

Dosing Considerations: Preparation and Storage of Parenteral Solution: Tap vial gently to loosen powder. Use only Sterile Water for injection. Immediate use of reconstituted solutions is recommended, however reconstituted solutions may be stored for up to 24 hours at controlled room temperature not exceeding 25°C or 48 hours under refrigeration. Products should be reconstituted as directed as follows and may be added to an appropriate infusion fluid in the amount calculated to give the desired dose.
For IM use: Using Sterile Water for Injection, reconstitute as follows: See Table 1.

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For IV Use: Using Sterile Water for Injection, reconstitute as follows: See Table 2.

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For IV Infusion: Using Sterile Water for Injection, reconstitute as follows: See Table 3.

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Cloxacillin for Injection should be reconstituted as described previously and added to an appropriate infusion fluid in the amount calculated to give the desired dose.
Recommended Dose and Dosage Adjustment: Adults: 250 to 500 mg i.m. or i.v. every 6 hours. I.V. dosage may be increased in serious infections. Maximum dosage for adults is 6 g/day.
Children (up to 20 kg): 25 to 50 mg/kg/day into 4 equal doses administered i.m. or i.v. every 6 hours.
Administration: IM/IV use: Shake well to dissolve. Administer total contents of vial by slow infusion over 2-4 minutes. Immediate use of the reconstituted solution is recommended.
IV Infusion: Shake well to dissolve. Administer total contents of vial by slow infusion over 30-40 minutes. Immediate use of the reconstituted solution is recommended.
Dispensing from Pharmacy Bulk Vial: The use of pharmacy bulk vial is restricted to hospitals with a recognized intravenous admixture program. The pharmacy bulk vial is intended for single puncture, multiple dispensing.