K-CIL

β-hemolytic streptococcal & pneumococcal infections & Staph infections (including those caused by β-lactamase producing organisms). Severe Staph infections (septicaemia, osteomyelitis, endocarditis, pneumonia) or when Staph are suspected & treatment is required before sensitivity results, followed by oral, when indicated.

IM/IV Adult 250-500 mg every 6 hr. IV dose may be increased in serious infections. Max: 6 g/day. Childn weighing up to 20 kg 25-50 mg/kg/day divided in 4 equal doses every 6 hr.

Hypersensitivity to cloxacillin Na, penicillins or cephalosporins.

Serious & occasionally fatal hypersensitivity (anaphylactoid) reactions in patients receiving penicillin or cephalosporin therapy; previous hypersensitivity reactions to penicillins, cephalosporins or other allergens. Discontinue treatment & administer antihistamines, pressor amines, corticosteroids if allergic or anaphylactic reactions, redness, irritation, or swelling occur; if results of identification & susceptibility testing indicate infection is due to organism other than penicillinase producing Staph susceptible to cloxacillin Na. Not effective against methicillin-resistant strains of Staph. CNS adverse effects including myoclonia, convulsive seizures & depressed consciousness. Candidiasis & other superinfections especially in debilitated & malnourished patients, or those w/ low resistance to infection due to corticosteroids, immunosuppressors or irradiation. Development of drug resistant bacteria. Consider culture & susceptibility information in selecting or modifying antibacterial therapy. Periodically check renal, hepatic & hematopoietic functions during long-term therapy. Pregnancy. Premature & newborn infants (frequent evaluation of organ system function).

Hypersensitivity (eg, fatal anaphylaxis), allergic reactions (rash, urticaria) including wheezing & sneezing; nausea, vomiting, epigastric discomfort, flatulence, loose stools; eosinophilia, leucopenia, anemia, thrombocytopenia, thrombocytopenic purpura, neutropenia, agranulocytosis; thrombophlebitis; mild SGOT level elevation (<100 u).

Enhanced serum conc w/ probenecid.

Penicillins

J01CF02 - cloxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections.

S