Particularly when given in high doses or in the presence of previous damage, some cardiovascular effects of verapamil may occasionally be greater than therapeutically desired: Reduction of heart rate (AV blockade, sinus bradycardia); lowering of blood pressure (hypotension); reduction of contractile force (more intense symptoms of heart failure).
Constipation is not infrequent and in rare cases, nausea, vertigo, dizziness, headache, flushing, fatigue, nervousness and ankle oedemas may occur.
Allergic skin reactions (erythema, pruritus, urticaria) were reported in single cases; furthermore, a reversible increase of transaminases and/or alkaline phosphatase, which is probably a sign of allergic hepatitis, may occur.
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