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Calcium antagonist.
Pharmacology: Verapamil reduces pathologically raised blood pressure by dilating the peripheral blood vessels. Peripheral resistance diminishes and the load on the heart is thus relieved.
In coronary insufficiency, verapamil reduces myocardial oxygen consumption directly by intervening in the energy-consuming metabolic processes of the myocardial cell and indirectly by diminishing afterload. Moreover, the decrease of the vascular smooth muscle tone prevents coronary spasms.
Verapamil has a pronounced antiarrhythmic action, particularly in supraventricular cardiac arrhythmias. It prolongs impulse conduction in the AV node and thereby restores the sinus rhythm and/or normalizes the ventricular rate.
