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Acute overdosage of Dopamine may result in excessive elevation of blood pressure. The rate of infusion of Dopamine should be decreased or the drug should be discontinued temporarily until the patient is stabilized. Because of Dopamine's short duration of action, these measures usually provide adequate management of toxicity. In cases of severe toxicity, administration of a short-acting α-adrenergic blocking agent (e.g., phentolamine) should be considered.