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Monoamine oxidase inhibitors: Because Dopamine is metabolized by monoamine oxidase (MAO), the effects of the drug are prolonged and intensified by MAO inhibitors. Patients who have been receiving MAO inhibitors within the previous 2-3 weeks should receive initial doses of Dopamine of no greater than 10% of the usual dose.
α-Adrenergic blocking agents: The peripheral vasoconstriction caused by high doses of Dopamine is antagonized by α-adrenergic blocking agents.
General anesthetics: Ventricular arrhythmias may occur when usual doses of Dopamine are administered during halothane (orother halogenated hydrocarbon) or cyclopropane anesthesia.
Phenytoin: Administration of IV phenytoin to patients receiving Dopamine has resulted in hypotension and bradycardia.
Other drugs: The pressor response of Dopamine may be potentiated by tricyclic antidepressants. The concomitant use of Dopamine with other vasopressors or vasoconstrictors (e.g., ergonovine) may result in severe hypertension.
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