Igamad Dosage/Direction for Use

Slow injection by the i.m. route.
In case of haemorrhagic disorders where intramuscular injections are contraindicated, human anti-D (Rh) immunoglobulin may be administered subcutaneously. Careful manual pressure with a compress should be applied to the site after injection.
If large total doses (> 5 ml) are required, it is advisable to administer them in divided doses at different sites.
1. In connection with pregnancy, child birth and gynaecological interventions: Postpartum prophylaxis: 1000 - 1500 IU (200 - 300 µg) is recommended as an optimal standard dose without previous testing for infiltration of HbF cells (Kleihauer-Betke test).
The injection should be given to the mother as soon as possible after delivery, but not later than 72 hours postpartum.
If a large foeto-maternal haemorrhage is suspected, its extent should be determined by a suitable method and additional doses of anti-D should be administered as indicated.
Antepartum and postpartum prophylaxis: 1000 - 1500 IU (200 - 300 µg) in the 28th week of pregnancy; in some cases, it is justified to initiate prophylaxis earlier. A further dose of 1000 - 1500 IU (200 - 300 µg) should be given within 72 hours after delivery if the newborn is Rh(D) positive.
If a large foeto-maternal haemorrhage is suspected, its extent should be determined by a suitable method and additional doses of anti-D should be administered as indicated.
After interruption of pregnancy, extrauterine pregnancy or hydatidiform mole: before the 12th week of pregnancy: 600 - 750 IU (120 to 150 µg) if possible within 72 hours of the event; after the 12th week of pregnancy: 1250 - 1500 IU (250 to 300 µg) if possible within 72 hours of the event.
After amniocentesis or chorion biopsy: 1250 - 1500 IU (250 to 300 µg) if possible within 72 hours of the intervention.
2. Following a transfusion of Rh-incompatible blood: Per 10 ml of transfused blood administer 500 IU to 1250 IU (100 to 250 µg) over a period of several days.