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The action of Isosorbide dinitrate is the relaxation of both arterial and venous vascular smooth muscle, including coronary artery. Isosorbide dinitrate is absorbed from the sublingual mucosa. When administered sublingually, Isosorbide dinitrate has an onset of action of 2-5 minutes and duration of relief from angina pectoris is 1-3 hours. After oral administration, the action of drug begins in 20-40 minutes and lasts 4-6 hours.