Gabutin Drug Interactions

Antacids: Co-administration of Gabapentin with antacid reduces Gabapentin bioavailability by about 20%.
Bioavailability of Gabapentin was reduced by 5% in 2 hours after antacid administration. It is recommended that Gabapentin should be taken at least 2 hours following antacid administration.
Cimetidine: Cimetidine seemed to alter the renal excretion of Gabapentin and creatinine. This is not expected to be of clinical importance.
Morphine: When 60 mg morphine was administered 2 hours prior to 600 mg oral Gabapentin, mean Gabapentin AUC increased by 44%. The magnitude of interaction at other doses is not known.
Oral contraceptive: Co-administration of Gabapentin with oral contraceptive containing norethindrone increased norethindrone AUC 13%, but it's not expected to be of clinical importance.
Naproxen: Co-administration of Gabapentin 125 mg with naproxen 250 mg capsule increased mean absorption of Gabapentin 12%-15%.
Ethanol: Ethanol may increase central nervous system depression.
Food: No significant effect on rate or extent of absorption.
Drug/lab test interaction: False positive have been reported with the Ames N-Multistix SG dipstick test when gabapentin was added to other anticonvulsant drugs. To determine urinary protein, the more specific sulfosalicylic acid precipitation procedure is recommended.
No pharmacokinetic interaction between Gabapentin and phenobarbital, phenytoin, valproic acid, or carbamazepine has been observed.