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Doses up to 4,800 mg/day have been well tolerated in clinical studies. The maximum time between doses in the three times a day schedule should not exceed 12 hours to prevent breakthrough convulsions. (See Table 1.)
Click on icon to see table/diagram/imageChildren 3-12 years: An initial dosage regimen is 10-15 mg/kg/day in 3 divided doses, the interval between doses should not exceed 12 hours; titrate to effective dose over approximately 3 days; dosages of up to 50 mg/kg/day have been tolerated in clinical studies.
In children 5-12 years of age, the maintenance dosage of Gabapentin is 25-35 mg/kg daily administered in 3 divided doses; for children 3-4 years of age, the dosage of Gabapentin is 40 mg/kg daily administered in 3 divided doses.
Neuropathic pain in adults: The starting dose is 900 mg/day given in three equally divided doses; the dosage may be increased following Table 1, and increased if necessary, based on response, up to a maximum dose of 3,600 mg/day. Therapy should be initiated by titrating the dose (three times a day).
Elderly: Studies in elderly patients have shown a decrease in clearance as age increases. This is most likely due to age-related decreases in renal function; dose reductions may be needed.
Renal function impairment: Dose adjustment is recommended in patients with compromised renal function and/or in those undergoing hemodialysis. (See Table 2.)
Click on icon to see table/diagram/imageDose adjustment in patients undergoing hemodialysis: For patients undergoing hemodialysis who have never received Gabapentin, a loading dose of 300 mg to 400 mg is recommended, and then 200 mg to 300 mg of Gabapentin following each 4 hours of hemodialysis.
Hepatic function impairment: No information.
