Fosmicin Caution For Usage

Fosmicin for IV use should be administered only by IV route. In addition, it is advisable for the administration to be performed by IV drip infusion whenever possible.
It is known that phlebitis and angialgia may occur following the IV administration of Fosmicin. Therefore, sufficient care should be taken with regard to the selection of the injection site and the technique to be employed for the administration, and the rate at which the drug solution is injected should be as slow as possible.
Note: When Fosmicin for IV use is dissolved, heat is released; this has no detrimental effect on the drug or its activity, and is therefore no cause for worry.
When 1 g of Fosmicin for IV use was dissolved in 20 and 100 mL each of distilled water for injection, physiological saline and 5% glucose solution, and the resultant solutions were preserved for 7 days, there were almost no change in the potency, pH or appearance, indicating that the solutions are stable.
The same results were obtained with 2 g of Fosmicin for IV use when tested by the previously mentioned method.