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Because of the slow onset of hypotensive effect with extended-release tablets containing felodipine, these dosage forms are not suitable for use as acute therapy in rapidly reducing blood pressure in patients with severe hypertension in whom reduction of blood pressure was considered urgent (i.e., hypertensive urgencies) nor in hypertensive emergencies.
Concomitant administration of drugs that strongly induce or inhibit CYP3A4 enzymes result in extensively decreased or increased plasma levels of felodipine, respectively. Therefore, such combinations should be avoided.
Felodipine may cause significant hypotension with subsequent tachycardia. This may lead to myocardial ischaemia in susceptible patients.
Propensity for tachycardia.
Secondary prevention of myocardial infarction.
Malignant hypertension.
Severe left ventricular dysfunction.
Mild gingival enlargement has been reported in patients with pronounced gingivitis/periodontitis. The enlargement can be avoided or reversed by careful dental hygiene.
Felodipine is cleared by the liver. Consequently higher therapeutic concentrations and response can be expected in patients with clearly reduced liver function.
Felodipine contains lactose and patients with hereditary galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Felodipine.
Effect on ability to drive and use machine: Patients should know how they react to felodipine before they drive or use machines because occasionally dizziness or fatigue may occur.
