Felodipin Stada 5 Retard Dosage/Direction for Use

Recommended Dose: Adults: Hypertension: The dose should be adjusted to the individual requirements of the patient. The recommended starting dose is 5 mg once daily. Depending on the patient's response, the dosage can, where applicable be decreased to 2.5 mg or increased to 10 mg daily. Alternatively, dosage can be initiated at 2.5 mg daily and titrated upward according to blood pressure response and patient tolerance. The usual maintenance dosage is 2.5-10 mg given once daily.
If necessary another antihypertensive agent may be added. The standard maintenance dose is 5 - 10 mg once daily. Doses higher than 20 mg daily are not usually needed. For dose titration purposes a 2.5 mg tablet is available.
Stable angina pectoris: The dose should be adjusted individually. Treatment should be started with 5 mg once daily and if needed be increased to 10 mg once daily.
Felodipine can be used in combination with beta-blockers, ACE inhibitors or diuretics. The effects on blood pressure are likely to be additive and combination therapy will usually enhance the antihypertensive effect. Care should be taken to avoid hypotension.
Elderly population: Initial treatment with lowest available dose should be considered. The usual initial dose is 2.5 mg daily.
Hepatic impairment: Patients with impaired hepatic function may have elevated plasma concentrations of felodipine and may respond to lower doses. US licensed product information recommends that an initial dose of 2.5 mg once daily should be used in patients with hepatic impairment.
Renal impairment: Dose adjustment is not needed in patients with impaired renal function. The pharmacokinetics are not significantly affected in patients with impaired renal function.
Pediatric population: There is limited clinical trial experience of the use of felodipine in hypertensive pediatric patients. Felodipine is not recommended in children.
Mode of administration: Felodipine is administered orally. The tablets should be taken in the morning and be swallowed with water.
In order to keep the prolonged release properties, Felodipine film-coated tablet must not be divided, chewed or crushed. The tablets can be administered without food or following a light meal not rich in fat or carbohydrate.