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Symptoms: Overdosage may cause excessive peripheral vasodilatation with marked hypotension and sometimes bradycardia.
Management: Activated charcoal, induction of vomiting or gastric lavage. If appropriate or indicated. Severe hypotension should be treated symptomatically with the patient placed supine and the legs elevated. In case of accompanying Bradycardia, atropine 0.5-1 mg should be administered intravenously. If this is not sufficient, plasma volume should be increased by infusion of e.g. glucose, saline or dextran. Sympathomimetic drugs with predominant effect on the α1-adrenoceptor may be given e.g. metaraminol or phenylephrine if the previously-mentioned measures are insufficient.
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