Erimycin For Suspension Special Precautions

Hepatic function impairment including increased liver enzymes, and hepatocellular and/or cholestatic hepatitis, with or without jaundice has occurred in patients receiving oral Erythromycin. Use caution with hepatic impairment with or without jaundice.
Macrolides have been associated with rare QTc prolongation and ventricular arrhythmias, including torsade de pointes. Avoid use in patients with prolonged QT interval, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia or concurrent use of Class IA (i.e. quinidine, procainamide) or Class III (i.e. amiodarone, dofetilide, sotalol) antiarrhythmic agents.
Prolonged use may result in fungal or bacterial superinfection including Clostridium difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed > 2 months post-antibiotic treatment.
Erythromycin may aggravate muscle weakness in patients with myasthenia gravis.
Use in Children: Use in infants has been associated with infantile hypertrophic pyloric stenosis (IHPS).