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Erythromycin is indicated for the treatment of infections caused by susceptible strains in the following diseases: 1. Respiratory tract infection: Upper respiratory tract infection of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides). Lower respiratory tract infection of mild to moderate severity caused by Streptococcus pneumoniae or Streptococcus pyogenes. Moreover, respiratory tract infection due to Mycoplasma pneumoniae.
2. Skin infection: Mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus.
3. Erythrasma caused by Corynebacterium minutissimum.
4. Prevention of initial attacks of rheumatic fever and prevention of recurrent attacks of rheumatic fever: As an alternative treatment in penicillin-allergic patients.
5. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative treatment in penicillin-allergic patients.
6. Nongonococcal urethritis: As an alternative to azithromycin or doxycycline for the treatment of nongonococcal urethritis that caused by Ureaplasma urealyticum.
7. Chlamydial infections: As an alternative to azithromycin or tetracyclines for the treatment of uncomplicated urethral, endocervical or rectal infections that caused by Chlamydia trachomatis. Moreover, the treatment of chlamydial urogenital infections during pregnancy and the treatment of pneumonia or ophthalmic neonatorum in infants caused by C. trachomatis are used.
8. Diphtheria caused by Corynebacterium diphtheriae, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers.
9. Pertussis caused by Bordetella pertussis.
10. Legionnaire disease caused by Legionella pneumophila.
11. Intestinal amebiasis caused by Entamoeba histolytica.
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