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Some adverse events, including skin eruptions and seizure, were previously reported in patients with eperisone intoxication. A case series of 13 patients who intentionally overdosed on eperisone were identified and the main symptoms were nausea in 6 patients, conscious disturbances in 4 patients, convulsions in 2 patients, and hypotension in 1 patient. Positive correlations between serum eperisone concentration and QTc interval in patients who overdosed on eperisone were demonstrated. Four patients developed QT prolongation following an overdose of eperisone, either alone or in combination with various other drugs. All patients were treated with gastric lavage and activated charcoal.