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Pharmacology: Pharmacodynamics: Eperisone reduces alpha- and gamma-efferent activities and inhibits spinal cord activities by acting on the spinal cord and supraspinal structures.
In healthy volunteers, eperisone (150 and 300 mg/day) suppressed spontaneous contraction of muscle spindle, as well as static and dynamic responses to stretch.
In addition to its relaxant effect, eperisone exerts a vasodilatory activity, thus increasing muscle blood flow and is associated to antinociceptive effects by inhibiting the release of P substance. When eperisone hydrochloride is used in the treatment of spastic paralysis in patients with cerebral apoplexy, it improves the cybex torque curve and electromyogram and facilitates voluntary movements, such as extension and flexion of the extremities, without reducing the muscular force.
Pharmacokinetics: Half-life elimination: 1.6 to 1.8 hours.
Time to peak: 1.6 to 1.9 hours.
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