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There is no specific antidote for cytarabine overdose. Cessation of therapy followed by management of ensuing bone marrow depression including whole blood or platelet transfusion and antibiotics as required.
Twelve doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours induce irreversible and fatal CNS toxicity.
Cytarabine may be removed by haemodialysis.
Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity.
