Cytarine Caution For Usage

Handling and Disposal: Procedures for proper handling and disposal of anti-cancer drugs should be considered. Only persons conversant with standard practices of handling and disposal of anticancer agents should handle cytarabine. Unused portion and all materials that have been utilized for dilution and administration should be disposed of according to standard procedures of anticancer drugs.
Solutions of cytarabine have been reported to be incompatible with various drugs, i.e. fluorouracil, gentamicin sulphate, heparin sodium, hydrocortisone sodium succinate, insulin-regular, methylprednisolone sodium succinate, nafacillin sodium, oxacillin sodium, penicillin G sodium. However, the incompatibility depends on several factors (e.g. concentrations of the drug, specific diluents used, resulting pH, temperature). Specialised references should be consulted for specific compatibility information.
Parenteral drugs should be inspected visually for particulate matter and discoloration, prior to administration, whenever solution and container permit.
Special Precautions for Handling: If crystallization is observed as a result of exposure to low temperatures, redissolve the crystals by warming up to 55°C for no longer than 30 minutes and shake until the crystals are dissolved. Allow to cool prior to use.