Ciflo Warnings

If a patient experience a rash, joint pain, muscle pain, or pain in the tendons of the wrists or ankles after using this medicine, stop taking it immediately and consult a doctor.
This medicine may cause harm to the liver and kidneys.
Use cautiously in patients taking drugs metabolized by cytochrome P450 1A2 (e.g., theophylline, methylxanthine, caffeine), as ciprofloxacin may interfere with drug metabolism and increase plasma levels, leading to toxicity.
Blood disorders, including bone marrow suppression, may occur. If found, the drug should be stopped immediately. Using this drug together with warfarin may increase the effect of warfarin.
Avoid prolonged exposure to sunlight or ultraviolet (UV) light, as ciprofloxacin may cause phototoxicity. Rare but serious adverse reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme.
This drug may affect blood sugar level changes. Caution should be exercised in diabetic patients.
250 mg: History of allergic reactions to other quinolone antibiotics.
Pregnancy and lactation, unless the potential benefits outweigh the risks.
Avoid patients with a history of epilepsy or other central nervous system (CNS) disorders prone to seizures.
Ciprofloxacin should be administered to patients with a history of seizures only if appropriate and proven seizure prevention or treatment is available. Ciprofloxacin absorption is reduced when given with antacids containing aluminum and magnesium hydroxide; therefore, the two drugs should not be taken together. Ciprofloxacin should be given 1 to 2 hours before or after antacids. Co-administration of Ciprofloxacin (1500 mg or more per day) and theophylline may result in higher than desired blood theophylline concentrations.
500 mg: Do not use in people who are allergic to this drug or other quinolone drugs.
Pregnant and breastfeeding women should avoid using this drug.
This drug should not be used, or if necessary, should be used with caution in patients with central nervous system disorders who are prone to seizures, in relation to the dose given.