May increase levels/effect of prilocaine. Increased levels/effect w/ abiraterone acetate, amiodarone, β-blockers, conivaptan, moderate & strong CYP1A2 & CYP3A4 inhibitors, darunavir, dasatinib, deferasirox, disopyramide, hyaluronidase, ivacaftor, mifepristone, saquinavir, telaprevir. Decreased levels/effect w/ strong CYP1A2 & CYP3A4 inducers, cyproterone, deferasirox, tocilizumab, etravirine; herb & nutraceutical.