Cefspan Special Precautions

General Precautions: Careful inquiry about any form of hypersensitivity should be made, since reactions such as shock may occur.
Careful Administration: Patients with a history of hypersensitivity to penicillins; patients with a personal or familial history of some form of allergy such as bronchial asthma, rash, urticaria; patients with serious renal function disorder; patients with poor oral nutrition, patients receiving parenteral nutrition; elderly patients or patients in a debilitated state: Careful observation is essential in these patients as vitamin K deficiency symptoms may develop.
Influences on Laboratory Values: False-positive results may occur with urine-sugar tests using Benedict's solution, Fehling's solution and Clinitest. False-positives have not been reported with TesTape.
A positive direct Coombs' test may occur.
Impairment of Fertility: In studies where infant rats were given ≥1000 mg/kg/day orally, a reduced spermatogenesis was reported.
Use in Pregnancy: Safety during pregnancy has not been established. Cefspan should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.
Use in Children: Safety in newborns or prematures has not been established.
Use in Elderly: This product should be administered with care and attention to the following points while closely monitoring the patient's condition such as paying special attention to the dose and dosing interval.
Adverse reactions are likely to occur in the elderly due to reduced physiological functions.
Bleeding tendency due to vitamin K deficiency may occur in the elderly.