Cefspan Description

CEFSPAN Capsules 100 mg contain 100 mg (potency) of cefixime and powder for oral suspension contains 100 mg (potency) of cefixime per 5 mL (when reconstituted).
CEFSPAN is an oral cephem derivative developed by the Central Research Laboratories of Fujisawa Pharmaceutical Co., Ltd. Generically, it is called cefixime, which has a vinyl group at the 3 position and a carboxymethoxyimino group at the 7 position of 7-aminocephalosporanic acid.
This product is stable to various β-lactamases, differing from previous oral cephems and penicillins. It has broad-spectrum activity against gram-positive and -negative microorganisms; in particular, it has good activity against gram-negative bacilli. Its mode of action is bactericidal. It produces a maximum serum concentration 4 hours after oral administration, so with its prolonged serum concentration and urinary excretion, and its high biliary concentration, efficacy with twice daily dosing is possible.
Nonproprietary name: Cefixime (JAN, INN)
Abbreviation: CFIX
Chemical name: (-)-(6R,7R)-7-[(Z(-2-(2-Amino-4-thiazol-yl)-2-(carboxymethoxyimino) cetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
Molecular formula: C₁₆H₁₅N₅O₇S₂.
Molecular weight: 453.46.
Melting point: Approx. 240°C (decomposition).
Partition coefficient: 2.9x10^-3 (1-octanol/water system).
Cefixime occurs as a white to light yellow crystalline powder with little or no characteristic odor. Cefixime is freely soluble in methanol, slightly soluble in ethanol, and practically insoluble in water or ether.