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Pharmacology: Mechanism of Action: Its mode of action is inhibition of cell wall synthesis. It has high affinity for penicillin binding proteins (PBP) 1 (1a, 1b and 1c) and 3, with the site of activity varying according to organism.
Microbiology: Antibacterial Activity: Cefixime has broad-spectrum activity against gram positive and -negative microorganisms. In particular, in comparison with the other oral cephalosporins, it has potent activity against such gram-positive organisms as Streptococcus sp., Streptococcus pneumoniae, and such gram-negatives as Neisseria gonorrhoeae, Moraxella catarrhalis, Escherichia coli, Klebsiella sp., Serratia sp., Proteus sp., Haemophilus influenzae. Its mode of action is bactericidal.
It is extremely stable to β-lactamase produced by many organisms, and has good activity against β-lactamases producing organisms.
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