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Dipyridamole inhibits adenosine cellular uptake and metabolism, and potentiates the action of adenosine. Asystole has been reported following concomitant administration. It is therefore suggested that adenosine injection should not be administered to patients receiving dipyridamole; if use of adenosine injection is essential, dipyridamole should be stopped 24 hours before hand, or the dose of adenosine should be greatly reduced.
Theophylline and other xanthenes (methylxanthines) are competitive adenosine antagonists and should be avoided for 24 hours prior to use of adenosine. Food and drinks containing xanthines (tea, coffee, chocolate and cola) should be avoided for at least 12 hours prior to use of adenosine injection or larger doses of adenosine may be required. Adenosine may interact with drugs tending to impair cardiac conduction.
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