Adenozin Mechanism of Action

Other Cardiac Preparations. ATC Code: C01EB10.
Pharmacology: Pharmacodynamics: Endogenous nucleoside with peripheral vasodilator/antiarrhythmic effect.
Antiarrhythmic Drug: Adenosine is a purine nucleoside which is present in all cells of the body.
Adenosine administered by intravenous injection slows conduction through the AV node. This action can interrupt re-entry circuits involving the AV node and restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia. Once the circuit has been interrupted, the tachycardia stops and normal sinus rhythm is re-established. One acute interruption of the circuit is usually sufficient to arrest the tachycardia.
Pharmacokinetics: It is impossible to study adenosine in classical pharmacokinetic studies. It is present in various forms in all cells of the body where it plays an important role in energy production and utilization systems. An efficient salvage and recycling system exists in the body, primarily in the erythrocytes and blood vessel endothelial cells. The half-life in vitro is estimated to be less than 10 seconds.
Onset of action: rapid. Duration: very brief.