Nazolin

Oxymetazoline Hydrochloride, the active ingredient of Nazolin nasal spray, is a sympathomimetic amine of the imidazoline class. The chemical name of the active ingredient is 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline hydrochloride.

As a nasal decongestant in allergic rhinitis, with or without the addition of topical antihistamines or sodium cromoglycate.
As a nasal decongestant in sinusitis where there is evidence of obstruction of ostea to the sinuses.
As a nasal decongestant in otitis media where there is evidence of obstruction of eustachian tube, especially in subacute serious otitis media ('glue ear') and otitic barotrauma.
As a decongestant in an infective rhinitis (e.g. an acute viral upper respiratory tract infection). Where there is a secondary bacterial infection, there is no evidence of benefit.

For nasal use, 2-3 sprays should be instilled into each nostril twice a daily.
The nasal spray can be used with the patient in the upright position. Sprays are generally unsuitable for young children because of the small size of their nostril.
A treatment course should not normally exceed three to five days, and on no account should it be continued for longer than two weeks because of the risk of developing 'rhinitis medicamentosa'.

As a sympathomimetic, oxymetazoline should not be used in patients being simultaneously treated with monoamine oxidase inhibitor therapy.
Narrow-angle glaucoma.
The safety of use in pregnancy has not fully been established and administration of oxymetazoline should be avoided unless absolutely essential.

The drug should be used with caution in patients suffering from Coronary Artery Disease, hypertension, hyperthyroidism, diabetes mellitus.

The safety of use in pregnancy has not fully been established and administration of oxymetazoline should be avoided unless absolutely essential.

Used correctly (as an intranasal application), the local vasoconstriction produced by the drug inhibits the absorption and a systemic action is unlikely. If however, some of the drops are swallowed, they can be absorbed form the gastrointestinal tract and a systemic effect can be produced. In children an overdose, if swallowed and absorbed, has been reported to cause sedation. As oxymetazoline is an α₂ adrenergic agonist, it might be expected to produce effects similar to those of clonidine, with a short-lived rise in pressure caused by a peripheral action, followed by more prolonged hypotension and sedation as a result of inhibition of sympathetic outflow from brain.
Overuse is associated with a more persistent rhinitis related to the rebound phenomenon-the condition known as 'rhinitis medicamentosa' (often spoken of as 'nose-drop nose'). It is claimed that, because of its more prolonged action, oxymetazoline is likely to cause rebound congestion than other decongestants.
Stinging, discomfort or a dryness locally in the nose or eye is encountered infrequently. If the symptoms persist, the discomfort from the use of the drops probably outweighs any advantage they may confer. Headache has been reported, albeit infrequently as has tachycardia.

Patient Information: Before using Nazolin nasal spray: 1. Shake the bottle gently, then remove the dust cap.
2. Hold the bottle with the forefinger and middle finger on either side of the nozzle and the thumb underneath the bottle.
3. Before using the nasal spray for the first time, or if the patient has not used it for a longer period, with the nozzle pointing away from from the patient, press several times until a fine uniform mist comes out of the nozzle.
4. Blow nose gently.
5. Close one nostril and put the nozzle in other nostril, tilt head slightly forward keeping the nozzle in the upright position.
6. Start to breathe in through the nose and while breathing in, press down with fingers once to release a spray.
7. Breathe out through the mouth. Repeat steps 6 and 7 to have a second spray.
8. Repeat steps 5, 6, and 7 for the other nostril.
9. After use: Wipe the nozzle with a clean cloth and replace the dust cap.
Cleansing: The nasal spray should be cleaned at least once a week.
1. Push the nozzle upwards to detach form the bottle.
2. Wash the nozzle and dust cap in warm water. Shake off excess water and leave to dry in warm place. Avoid excessive heat.
3. Replace the nozzle and dust cap.
4. If the nozzle becomes blocked, remove it and soak in warm water. Rinse under a cold tap. Allow to dry and refit. Do not use a pin or other sharp objects to unblock the nozzle.
Note: The first time the patient use nasal spray, the patient may sneeze a few times. This is because the lining of the nose is very sensitive. This is not likely to happen after the first few dose. The medication, at times cause, a few side effects in certain hypersensitive individuals. If the patient notice any bleeding from the nose or experience any other discomfort, please inform physician.
Use as directed by the physician. Do not exceed recommended dose. Keep out of reach of children.

Nazolin nasal spray should be stored at a temperature below 30°C.
Protect from frost and direct sunlight.
Shelf-Life: 2 months upon opening.

Nasal Decongestants & Other Nasal Preparations

R01AA05 - oxymetazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.

GSL