Nazolin Side Effects

Used correctly (as an intranasal application), the local vasoconstriction produced by the drug inhibits the absorption and a systemic action is unlikely. If however, some of the drops are swallowed, they can be absorbed form the gastrointestinal tract and a systemic effect can be produced. In children an overdose, if swallowed and absorbed, has been reported to cause sedation. As oxymetazoline is an α₂ adrenergic agonist, it might be expected to produce effects similar to those of clonidine, with a short-lived rise in pressure caused by a peripheral action, followed by more prolonged hypotension and sedation as a result of inhibition of sympathetic outflow from brain.
Overuse is associated with a more persistent rhinitis related to the rebound phenomenon-the condition known as 'rhinitis medicamentosa' (often spoken of as 'nose-drop nose'). It is claimed that, because of its more prolonged action, oxymetazoline is likely to cause rebound congestion than other decongestants.
Stinging, discomfort or a dryness locally in the nose or eye is encountered infrequently. If the symptoms persist, the discomfort from the use of the drops probably outweighs any advantage they may confer. Headache has been reported, albeit infrequently as has tachycardia.