Zyriz Special Precautions

Precaution is recommended if alcohol is taken concomitantly. If signs and symptoms such as formation of small pustules occur with or without pyrexia or erythema, then treatment with cetirizine should be discontinued and a physician should be consulted.
Effects on the Ability to Drive or Operate Machinery: Cetirizine hydrochloride should be used with caution in patients who require mental alertness or physical coordination in their work such as drivers or machine operators since it may cause drowsiness.
Use in Pregnancy: No data is available on the safety of administration of cetirizine hydrochloride in pregnant women apart from animal study which reveals absence of teratogenicity. As such, cetirizine hydrochloride must be given to pregnant patients only when necessary. Ask a physician before use if pregnant.
Use in Lactation: Cetirizine hydrochloride is excreted in breast milk. Thus, use in lactating mothers is not recommended. Ask physician before use if breastfeeding.
Use in Children: Use in infants and children must not be given cetirizine hydrochloride as this may increase the risk of experiencing antimuscarinic effects.
Use in the Elderly: Cetirizine hydrochloride must be used with caution in elderly patients who most likely have impaired renal and hepatic function. Since the drug is metabolized through the renal mechanism, half-life of cetirizine hydrochloride in such patients will be prolonged. Dose of the drug must be reduced in elderly patients.
Precaution is recommended if alcohol is taken concomitantly. If signs and symptoms such as formation of small pustules occur with or without pyrexia or erythema, then treatment with cetirizine should be discontinued and a physician should be consulted.